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KMID : 1141520180330030355
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Endocrinology and Metabolism
2018 Volume.33 No. 3 p.355 ~ p.363
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Factors Associated with Resolution of Hypertension after Adrenalectomy in Patients with Primary Aldosteronism
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Loh Wann Jia
Lim Dawn Shao Ting
Loh Lih Ming
Kek Peng Chin
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Abstract
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Background: The aim of this study was to investigate the factors associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism. A secondary aim was to describe our use of the contralateral ratio in adrenal venous sampling (AVS) in the setting of suboptimal successful cannulation rates.
Methods: A retrospective review of patients who underwent AVS followed by unilateral adrenalectomy for primary aldosteronism was performed.
Results: Complete resolution of hypertension and hypokalemia was seen in 17 of 40 patients (42.5%), while a clinical improvement in hypertension was seen in 38 of 40 (95%). Shorter duration of hypertension, mean aldosteronoma resolution score (ARS), and a high ARS of 3 to 5 were associated with resolution of hypertension after adrenalectomy (P=0.02, P=0.02, and P=0.004, respectively). Of the individual components of ARS, only a duration of hypertension of ≤6 years was associated with resolution of hypertension after adrenalectomy (P=0.03).
Conclusion: A shorter duration of hypertension was significantly associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism.
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KEYWORD
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Contralateral ratio, Adrenal venous sampling, Primary aldosteronism
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